ABOUT BREAST CANCER - Walk for Womens Cancer

ABOUT BREAST CANCER

Breast cancer occurs when abnormal cells in the breast grow in an uncontrolled way. Breast Cancer is the most common cancer in women of all ages.

One in 8 Australian women will be diagnosed with breast cancer by their 85th birthday. Thanks to medical research the 5 year survival for breast cancer has improved from 72% in 1987 to 90% in 2016, but there is more work to be done.

 
SIGNS AND SYMPTOMS
Become familiar with your own body! It’s important that you’re familiar with your breasts so that you’ll notice any changes that could be a sign of breast cancer. Most changes are not breast cancer, but if you find any changes it is important that you see your doctor straight away. Changes can include:

• A lump, lumpiness or thickening in the breast or under the arm

• New pain that doesn’t go away or pain that is only in one breast

• Dimpling, puckering or redness

• Changes to the nipple, such as inversion, discharge, bleeding, reddening or patchy areas, or itchy or ulcerated skin

• Changes to the shape and size of the breast

• Changes to the skin of the breast

• Changes in skin temperature of the breast
RISK FACTORS
Breast cancer can occur at any age, but the risk is greater if you are over the age of 50. No one thing causes breast cancer, but there are a number of factors that increase the risk:

• Family history of breast or ovarian cancer

• Inherited genetic factors such as BRAC1 or BRAC2

• Early menstruation

• Late menopause

• Exposure to hormones from oral contraceptives or hormone replacement therapy

• Never having given birth

• Giving birth for the first time over the age of 30

• Dense breast tissue

• Obesity, alcohol consumption, a lack of exercise and a poor diet
TREATMENT
Breast cancer treatment and care today is so customised that a specialised treatment plan is developed by a multidisciplinary team to meet the needs of the individual patient. Treatment can include:

• A lumpectomy to remove the tumour and a small area of healthy tissue around it

• A mastectomy to remove the entire breast and sometimes surrounding lymph nodes

• Radiation therapy uses x-rays to destroy cancer cells. It can be used before or after surgery to reduce the tumour size and make surgery easier

• Chemotherapy uses anti-cancer drugs to help destroy cancer cells in the breast, as well as breast cancer cells that may have spread to other areas of your body

• Biological therapy (or immunotherapy) helps the body's immune system fight cancer

• Hormonal therapies are treatments for women who have hormone receptors on their breast cancer cells. Hormonal therapies lower the level of female hormones in the body or change the way the body responds to female hormones
HOW PERKINS CAN HELP
Breast cancer research at the Perkins is focussed on determining the mechanisms that control how hormones and proteins control the growth and spread of tumours. This involves understanding how these hormones and proteins signal in the cancer cells to switch genes on or off.

By understanding how breast cancer functions on a cellular level, we will gain insights into better methods and treatments to stop the growth and spread of these diseases. Our laboratories have made several critical discoveries involving DNA-altering proteins that cut off the supply of blood and nutrition to tumour sites.
HOW YOU CAN HELP
Despite medical research delivering improved treatments, screening methods and prevention strategies, more than 3,000 Australian women lose their battle with breast cancer every year. More can be done, but we need your help. Commit to walk with the Harry Perkins Institute of Medical Research and raise vital funds to drive research breakthroughs that ultimately, save lives.
 
 

ABOUT TRIPLE NEGATIVE BREAST CANCER

It is now universally acknowledged that breast cancer is not one form of cancer, but many different subtypes of cancer. One of the most aggressive forms of breast cancer is known as ‘triple negative’ breast cancer.

Most breast cancer subtypes are diagnosed based on the presence, or lack of, three ‘receptors’. These are estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 (HER2). We now have drugs that can target these receptors and switch off the hormones that feed these types of cancer. The term ‘triple negative’ refers to the lack of receptors for all three of these drug targets.

This means that triple negative breast cancer does not respond to the most widely used breast cancer therapies. Instead, triple negative breast cancer treatment usually involves surgery, radiotherapy and chemotherapy. Tragically, if the triple negative cancer has spread to other parts of the body, it becomes resistant to chemotherapy and the prognosis becomes dire for patients. More than one in every ten breast cancers are found to be triple negative.

This is a key area which benefits from the funds raised by the Hawaiian Walk for Women's Cancer, to help the researchers at the Perkins continue to discover lifesaving discoveries that will find better treatments for these hard to treat women's cancers!

HOW PERKINS CAN HELP

The Harry Perkins Institute of Medical Research is focused on finding solutions for poor prognosis cancers, such as triple negative breast cancer.

In 2016, the Perkins announced that pre-clinical investigations into nanoparticle drug delivery technology had produced promising results. Nanoparticles are tiny objects that can be used to deliver anti-cancer medicine to individual cells. The nanoparticles developed at the Perkins have a molecule that functions like a GPS navigator and sends the anti-cancer medicine contained inside the nanoparticle, straight to the tumour site. Ultimately, this means that the treatment is more effective and has less side effects.